Ultralow-dose binary oncolytic/helper-dependent adenovirus promotes antitumor activity in preclinical and clinical studies

We show that a binary oncolytic/helper-dependent adenovirus (CAdVEC) that both lyses tumor cells and locally expresses the proinflammatory cytokine IL-12 and PD-L1 blocking antibody has potent antitumor activity in humanized mouse models. On the basis of these preclinical studies, we treated four pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Daniel, Porter, Caroline E., Lim, Bora, Rosewell Shaw, Amanda, Robertson, Catherine S., Woods, Mae L., Xu, Ya, Biegert, Greyson G.W., Morita, Daisuke, Wang, Tao, Grilley, Bambi J., Heslop, Helen, Brenner, Malcolm K., Suzuki, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058234/
https://www.ncbi.nlm.nih.gov/pubmed/36989357
http://dx.doi.org/10.1126/sciadv.ade6790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058234/
https://www.ncbi.nlm.nih.gov/pubmed/36989357
http://dx.doi.org/10.1126/sciadv.ade6790

Ejemplares similares