Hemagglutinin destabilization in H3N2 vaccine reference viruses skews antigenicity and prevents airborne transmission in ferrets

During influenza virus entry, the hemagglutinin (HA) protein binds receptors and causes membrane fusion after endosomal acid activation. To improve vaccine efficiency and pandemic risk assessment for currently-dominant H3N2 influenza viruses, we investigated HA stability of 6 vaccine reference virus...

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Detalles Bibliográficos
Autores principales: Hu, Meng, Kackos, Christina, Banoth, Balaji, Ojha, Chet Raj, Jones, Jeremy C., Lei, Shaohua, Li, Lei, Kercher, Lisa, Webby, Richard J., Russell, Charles J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058244/
https://www.ncbi.nlm.nih.gov/pubmed/36989367
http://dx.doi.org/10.1126/sciadv.adf5182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058244/
https://www.ncbi.nlm.nih.gov/pubmed/36989367
http://dx.doi.org/10.1126/sciadv.adf5182

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