Screening Autoxidation Propensities of Drugs in the Solid-State Using PVP and in the Solution State Using N-Methyl Pyrrolidone

Oxidative degradation of drugs is one of the major routes of drug substance and drug product instability. Among the diverse routes of oxidation, autoxidation is considered to be challenging to predict and control, potentially due to the multi-step mechanism involving free radicals. C–H bond dissocia...

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Detalles Bibliográficos
Autores principales: Iyer, Jayant, Karn, Anjali, Brunsteiner, Michael, Ray, Andrew, Davis, Adrian, Saraf, Isha, Paudel, Amrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058359/
https://www.ncbi.nlm.nih.gov/pubmed/36986709
http://dx.doi.org/10.3390/pharmaceutics15030848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058359/
https://www.ncbi.nlm.nih.gov/pubmed/36986709
http://dx.doi.org/10.3390/pharmaceutics15030848

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