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NAADP-Evoked Ca(2+) Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
Huntington’s disease (HD) is a progressive neurodegenerative disease characterized by mutations in the huntingtin gene (mHtt), causing an unstable repeat of the CAG trinucleotide, leading to abnormal long repeats of polyglutamine (poly-Q) in the N-terminal region of the huntingtin, which form abnorm...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058390/ https://www.ncbi.nlm.nih.gov/pubmed/36982672 http://dx.doi.org/10.3390/ijms24065593 |