NAADP-Evoked Ca(2+) Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes

Huntington’s disease (HD) is a progressive neurodegenerative disease characterized by mutations in the huntingtin gene (mHtt), causing an unstable repeat of the CAG trinucleotide, leading to abnormal long repeats of polyglutamine (poly-Q) in the N-terminal region of the huntingtin, which form abnorm...

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Detalles Bibliográficos
Autores principales: Pereira, Cássia Arruda de Souza, Medaglia, Natalia de Castro, Ureshino, Rodrigo Portes, Bincoletto, Claudia, Antonioli, Manuela, Fimia, Gian Maria, Piacentini, Mauro, Pereira, Gustavo José da Silva, Erustes, Adolfo Garcia, Smaili, Soraya Soubhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058390/
https://www.ncbi.nlm.nih.gov/pubmed/36982672
http://dx.doi.org/10.3390/ijms24065593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058390/
https://www.ncbi.nlm.nih.gov/pubmed/36982672
http://dx.doi.org/10.3390/ijms24065593

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