Design, Synthesis and Biological Evaluation of Quinoline-8-Sulfonamides as Inhibitors of the Tumor Cell-Specific M2 Isoform of Pyruvate Kinase: Preliminary Study

Cancer cells need to carefully regulate their metabolism to keep them growing and dividing under the influence of different nutrients and oxygen levels. Muscle isoform 2 of pyruvate kinase (PKM2) is a key glycolytic enzyme involved in the generation of ATP and is critical for cancer metabolism. PKM2...

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Detalles Bibliográficos
Autores principales: Marciniec, Krzysztof, Rzepka, Zuzanna, Chrobak, Elwira, Boryczka, Stanisław, Latocha, Małgorzata, Wrześniok, Dorota, Beberok, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058396/
https://www.ncbi.nlm.nih.gov/pubmed/36985481
http://dx.doi.org/10.3390/molecules28062509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058396/
https://www.ncbi.nlm.nih.gov/pubmed/36985481
http://dx.doi.org/10.3390/molecules28062509

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