Cargando…

Valproic Acid Inhibits Progressive Hereditary Hearing Loss in a KCNQ4 Variant Model through HDAC1 Suppression

Genetic or congenital hearing loss still has no definitive cure. Among genes related to genetic hearing loss, the potassium voltage-gated channel subfamily Q member 4 (KCNQ4) is known to play an essential role in maintaining ion homeostasis and regulating hair cell membrane potential. Variants of th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nam, Yoon Seok, Choi, Young Mi, Lee, Sungsu, Cho, Hyong-Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058529/ https://www.ncbi.nlm.nih.gov/pubmed/36982769 http://dx.doi.org/10.3390/ijms24065695

Ejemplares similares

Overlooked KCNQ4 variants augment the risk of hearing loss
por: Oh, Kyung Seok, et al.
Publicado: (2023)

The Pathological Mechanisms of Hearing Loss Caused by KCNQ1 and KCNQ4 Variants
por: Homma, Kazuaki
Publicado: (2022)

Hyaluronan Synthase 1: A Novel Candidate Gene Associated With Late-Onset Non-syndromic Hereditary Hearing Loss
por: Umugire, Alphonse, et al.
Publicado: (2022)

Outcomes of Severe to Profound Idiopathic Sudden Sensorineural Hearing Loss
por: Jo, Si-Young, et al.
Publicado: (2015)

Avenanthramide-C prevents noise- and drug-induced hearing loss while protecting auditory hair cells from oxidative stress
por: Umugire, Alphonse, et al.
Publicado: (2019)

Cell death-inducing cytotoxicity in truncated KCNQ4 variants associated with DFNA2 hearing loss
por: Kojima, Takashi, et al.
Publicado: (2021)

Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss
por: Rim, John Hoon, et al.
Publicado: (2021)

Identification and Characterization of mRNA and lncRNA Expression Profiles in Age-Related Hearing Loss
por: Kim, Janghyun, et al.
Publicado: (2023)

Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss
por: Lee, Sang-Yeon, et al.
Publicado: (2021)

Exposure to valproic acid (VPA) reproduces hdac1 loss of function phenotypes in zebrafish
por: Jones, Alec A., et al.
Publicado: (2023)

Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss
por: Gao, Yanhong, et al.
Publicado: (2013)

HDAC inhibitor valproic acid upregulates CAR in vitro and in vivo
por: Segura-Pacheco, Blanca, et al.
Publicado: (2007)

In vivo outer hair cell gene editing ameliorates progressive hearing loss in dominant-negative Kcnq4 murine model
por: Noh, Byunghwa, et al.
Publicado: (2022)

Inhibition of leukemic cells by valproic acid, an HDAC inhibitor, in xenograft tumors
por: Zhang, Zhihua, et al.
Publicado: (2013)

Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19
por: Pitt, Bertram, et al.
Publicado: (2021)

Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss
por: Jung, Jinsei, et al.
Publicado: (2018)

Using Drosophila to study mechanisms of hereditary hearing loss
por: Li, Tongchao, et al.
Publicado: (2018)

Hereditary hearing loss SNP-microarray pilot study
por: Vona, Barbara, et al.
Publicado: (2018)

Navigating Hereditary Hearing Loss: Pathology of the Inner Ear
por: Nicolson, Teresa
Publicado: (2021)

Loss-of-function variants in the KCNQ5 gene are implicated in genetic generalized epilepsies
por: Krüger, Johanna, et al.
Publicado: (2022)

A KCNQ4 c.546C>G Genetic Variant Associated with Late Onset Non-Syndromic Hearing Loss in a Taiwanese Population
por: Yen, Ting-Ting, et al.
Publicado: (2021)

In silico modeling of the pore region of a KCNQ4 missense mutant from a patient with hearing loss
por: Namba, Kazunori, et al.
Publicado: (2012)

Protective Effect of Avenanthramide-C on Auditory Hair Cells against Oxidative Stress, Inflammatory Cytokines, and DNA Damage in Cisplatin-Induced Ototoxicity
por: Umugire, Alphonse, et al.
Publicado: (2023)

Preimplantation genetic testing for hereditary hearing loss in Chinese population
por: Bi, Qingling, et al.
Publicado: (2023)

Clinical Study of 30 Novel KCNQ2 Variants/Deletions in KCNQ2-Related Disorders
por: Xiao, Tiantian, et al.
Publicado: (2022)

Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss
por: Wei, Qinjun, et al.
Publicado: (2014)

Brief Report of Variants Detected in Hereditary Hearing Loss Cases in Iran over a 3-Year Period
por: BAZAZZADEGAN, Niloofar, et al.
Publicado: (2019)

Rare KCNQ4 variants found in public databases underlie impaired channel activity that may contribute to hearing impairment
por: Jung, Jinsei, et al.
Publicado: (2019)

Milestones toward cochlear gene therapy for patients with hereditary hearing loss
por: Yoshimura, Hidekane, et al.
Publicado: (2021)

Correction to: Preimplantation genetic testing for hereditary hearing loss in Chinese population
por: Bi, Qingling, et al.
Publicado: (2023)

Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea
por: Hosoya, Makoto, et al.
Publicado: (2016)

KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3
por: Soh, Heun, et al.
Publicado: (2022)

Loss of KCNQ2 or KCNQ3 Leads to Multifocal Time-Varying Activity in the Neonatal Forebrain Ex Vivo
por: Hou, Bowen, et al.
Publicado: (2021)

Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss
por: Haraksingh, Rajini R, et al.
Publicado: (2014)

HDAC2 Inhibitor Valproic Acid Increases Radiation Sensitivity of Drug-Resistant Melanoma Cells
por: Kalal, Bhuvanesh Sukhlal, et al.
Publicado: (2019)

LncRNA-BC069792 suppresses tumor progression by targeting KCNQ4 in breast cancer
por: Zhang, Yunxiang, et al.
Publicado: (2023)

Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3
por: Leng, Yan, et al.
Publicado: (2016)

Frequency of KCNQ1 variants causing loss of methylation of Imprinting Centre 2 in Beckwith-Wiedemann syndrome
por: Eßinger, Carla, et al.
Publicado: (2020)

Transcanal Endoscopic Tympanoplasty for Pediatric Patients Under 15 Years of Age With Chronic Otitis Media
por: Lee, Sungsu, et al.
Publicado: (2020)

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
por: Klein, Christopher J., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_qi0if4be5041cmeokfgkr4cfqk