Use of In Vitro Dynamic Colon Model (DCM) to Inform a Physiologically Based Biopharmaceutic Model (PBBM) to Predict the In Vivo Performance of a Modified-Release Formulation of Theophylline

A physiologically based biopharmaceutic model (PBBM) of a modified-release formulation of theophylline (Uniphyllin Continus(®) 200 mg tablet) was developed and implemented to predict the pharmacokinetic (PK) data of healthy male volunteers by integrating dissolution profiles measured in a biorelevan...

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Detalles Bibliográficos
Autores principales: Stamatopoulos, Konstantinos, O’Farrell, Connor, Simmons, Mark J. H., Batchelor, Hannah K., Mistry, Nena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058579/
https://www.ncbi.nlm.nih.gov/pubmed/36986743
http://dx.doi.org/10.3390/pharmaceutics15030882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058579/
https://www.ncbi.nlm.nih.gov/pubmed/36986743
http://dx.doi.org/10.3390/pharmaceutics15030882

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