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Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications

Intrathecal pseudodelivery of drugs is a novel route to administer medications to treat neurodegenerative diseases based on the CSF-sink therapeutic strategy by means of implantable devices. While the development of this therapy is still in the preclinical stage, it offers promising advantages over...

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Autores principales: Manuel, Menéndez-González, Tamba, Bogdan-Ionel, Leclere, Maxime, Mabrouk, Mostafa, Schreiner, Thomas-Gabriel, Ciobanu, Romeo, Cristina, Tomás-Zapico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059785/
https://www.ncbi.nlm.nih.gov/pubmed/36986629
http://dx.doi.org/10.3390/pharmaceutics15030768
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author Manuel, Menéndez-González
Tamba, Bogdan-Ionel
Leclere, Maxime
Mabrouk, Mostafa
Schreiner, Thomas-Gabriel
Ciobanu, Romeo
Cristina, Tomás-Zapico
author_facet Manuel, Menéndez-González
Tamba, Bogdan-Ionel
Leclere, Maxime
Mabrouk, Mostafa
Schreiner, Thomas-Gabriel
Ciobanu, Romeo
Cristina, Tomás-Zapico
author_sort Manuel, Menéndez-González
collection PubMed
description Intrathecal pseudodelivery of drugs is a novel route to administer medications to treat neurodegenerative diseases based on the CSF-sink therapeutic strategy by means of implantable devices. While the development of this therapy is still in the preclinical stage, it offers promising advantages over traditional routes of drug delivery. In this paper, we describe the rationale of this system and provide a technical report on the mechanism of action, that relies on the use of nanoporous membranes enabling selective molecular permeability. On one side, the membranes do not permit the crossing of certain drugs; whereas, on the other side, they permit the crossing of target molecules present in the CSF. Target molecules, by binding drugs inside the system, are retained or cleaved and subsequently eliminated from the central nervous system. Finally, we provide a list of potential indications, the respective molecular targets, and the proposed therapeutic agents.
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spelling pubmed-100597852023-03-30 Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications Manuel, Menéndez-González Tamba, Bogdan-Ionel Leclere, Maxime Mabrouk, Mostafa Schreiner, Thomas-Gabriel Ciobanu, Romeo Cristina, Tomás-Zapico Pharmaceutics Review Intrathecal pseudodelivery of drugs is a novel route to administer medications to treat neurodegenerative diseases based on the CSF-sink therapeutic strategy by means of implantable devices. While the development of this therapy is still in the preclinical stage, it offers promising advantages over traditional routes of drug delivery. In this paper, we describe the rationale of this system and provide a technical report on the mechanism of action, that relies on the use of nanoporous membranes enabling selective molecular permeability. On one side, the membranes do not permit the crossing of certain drugs; whereas, on the other side, they permit the crossing of target molecules present in the CSF. Target molecules, by binding drugs inside the system, are retained or cleaved and subsequently eliminated from the central nervous system. Finally, we provide a list of potential indications, the respective molecular targets, and the proposed therapeutic agents. MDPI 2023-02-25 /pmc/articles/PMC10059785/ /pubmed/36986629 http://dx.doi.org/10.3390/pharmaceutics15030768 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Manuel, Menéndez-González
Tamba, Bogdan-Ionel
Leclere, Maxime
Mabrouk, Mostafa
Schreiner, Thomas-Gabriel
Ciobanu, Romeo
Cristina, Tomás-Zapico
Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications
title Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications
title_full Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications
title_fullStr Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications
title_full_unstemmed Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications
title_short Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications
title_sort intrathecal pseudodelivery of drugs in the therapy of neurodegenerative diseases: rationale, basis and potential applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059785/
https://www.ncbi.nlm.nih.gov/pubmed/36986629
http://dx.doi.org/10.3390/pharmaceutics15030768
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