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Association between Systemic Factors and Vitreous Fluid Cytokines in Proliferative Diabetic Retinopathy
Proliferative diabetic retinopathy (PDR) is a vision-threatening complication of diabetes mellitus (DM). Systemic and intraocular factors are intricately related to PDR, and vitreous fluid (VF) cytokines are representative intraocular biomarkers. However, the associations between systemic factors an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059790/ https://www.ncbi.nlm.nih.gov/pubmed/36983353 http://dx.doi.org/10.3390/jcm12062354 |
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author | Sato, Tomohito Okazawa, Rina Nagura, Koichi Someya, Hideaki Nishio, Yoshiaki Enoki, Toshio Ito, Masataka Takeuchi, Masaru |
author_facet | Sato, Tomohito Okazawa, Rina Nagura, Koichi Someya, Hideaki Nishio, Yoshiaki Enoki, Toshio Ito, Masataka Takeuchi, Masaru |
author_sort | Sato, Tomohito |
collection | PubMed |
description | Proliferative diabetic retinopathy (PDR) is a vision-threatening complication of diabetes mellitus (DM). Systemic and intraocular factors are intricately related to PDR, and vitreous fluid (VF) cytokines are representative intraocular biomarkers. However, the associations between systemic factors and VF cytokines and their influence on PDR pathology are unclear. This study aimed to examine the correlation between systemic factors and VF cytokines and analyze their contributions to the pathology of PDR using multivariate analyses. We conducted a retrospective observational study on 26 PDR eyes of 25 patients with type 2 DM, and 30 eyes of 30 patients with idiopathic macular hole or epiretinal membrane as controls. Fifteen systemic and laboratory tests including blood pressure (BP) and body mass index (BMI), and 27 cytokines in VF were analyzed. BP and BMI correlated positively with VF levels of IL-6 and IP-10 in PDR patients, while no significant correlation was found between systemic factors and VF cytokines in controls. MCP-1 and VEGF-A in VF separately clustered with different systemic factors in controls, but these cytokines lost the property similarity with systemic factors and acquired property similarity with each other in PDR. Systemic factors contributed to only 10.4%, whereas VF cytokines contributed to 42.3% out of 52.7% variance of the whole PDR dataset. Our results suggest that intraocular factors play a major role in the pathology of PDR, whereas systemic factors may have limited effects, and that BP and BMI control in PDR could be useful interventions to improve intraocular immune condition. |
format | Online Article Text |
id | pubmed-10059790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100597902023-03-30 Association between Systemic Factors and Vitreous Fluid Cytokines in Proliferative Diabetic Retinopathy Sato, Tomohito Okazawa, Rina Nagura, Koichi Someya, Hideaki Nishio, Yoshiaki Enoki, Toshio Ito, Masataka Takeuchi, Masaru J Clin Med Article Proliferative diabetic retinopathy (PDR) is a vision-threatening complication of diabetes mellitus (DM). Systemic and intraocular factors are intricately related to PDR, and vitreous fluid (VF) cytokines are representative intraocular biomarkers. However, the associations between systemic factors and VF cytokines and their influence on PDR pathology are unclear. This study aimed to examine the correlation between systemic factors and VF cytokines and analyze their contributions to the pathology of PDR using multivariate analyses. We conducted a retrospective observational study on 26 PDR eyes of 25 patients with type 2 DM, and 30 eyes of 30 patients with idiopathic macular hole or epiretinal membrane as controls. Fifteen systemic and laboratory tests including blood pressure (BP) and body mass index (BMI), and 27 cytokines in VF were analyzed. BP and BMI correlated positively with VF levels of IL-6 and IP-10 in PDR patients, while no significant correlation was found between systemic factors and VF cytokines in controls. MCP-1 and VEGF-A in VF separately clustered with different systemic factors in controls, but these cytokines lost the property similarity with systemic factors and acquired property similarity with each other in PDR. Systemic factors contributed to only 10.4%, whereas VF cytokines contributed to 42.3% out of 52.7% variance of the whole PDR dataset. Our results suggest that intraocular factors play a major role in the pathology of PDR, whereas systemic factors may have limited effects, and that BP and BMI control in PDR could be useful interventions to improve intraocular immune condition. MDPI 2023-03-17 /pmc/articles/PMC10059790/ /pubmed/36983353 http://dx.doi.org/10.3390/jcm12062354 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sato, Tomohito Okazawa, Rina Nagura, Koichi Someya, Hideaki Nishio, Yoshiaki Enoki, Toshio Ito, Masataka Takeuchi, Masaru Association between Systemic Factors and Vitreous Fluid Cytokines in Proliferative Diabetic Retinopathy |
title | Association between Systemic Factors and Vitreous Fluid Cytokines in Proliferative Diabetic Retinopathy |
title_full | Association between Systemic Factors and Vitreous Fluid Cytokines in Proliferative Diabetic Retinopathy |
title_fullStr | Association between Systemic Factors and Vitreous Fluid Cytokines in Proliferative Diabetic Retinopathy |
title_full_unstemmed | Association between Systemic Factors and Vitreous Fluid Cytokines in Proliferative Diabetic Retinopathy |
title_short | Association between Systemic Factors and Vitreous Fluid Cytokines in Proliferative Diabetic Retinopathy |
title_sort | association between systemic factors and vitreous fluid cytokines in proliferative diabetic retinopathy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059790/ https://www.ncbi.nlm.nih.gov/pubmed/36983353 http://dx.doi.org/10.3390/jcm12062354 |
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