A Self-Immolative Linker for the pH-Responsive Release of Amides

The administration of therapeutics using bioconjugation has been mainly limited to drugs containing amine, alcohol, or thiol functional groups. Here, we report a general procedure for the preparation of benzylic N-acyl carbamates suitable for masking the amide group in important drugs such as Linezo...

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Detalles Bibliográficos
Autores principales: Petrini, Agnese, Ievoli, Giovanni, Migliorini, Francesca, Taddei, Maurizio, Siciliano, Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060004/
https://www.ncbi.nlm.nih.gov/pubmed/36985417
http://dx.doi.org/10.3390/molecules28062445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060004/
https://www.ncbi.nlm.nih.gov/pubmed/36985417
http://dx.doi.org/10.3390/molecules28062445

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