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A Self-Immolative Linker for the pH-Responsive Release of Amides

The administration of therapeutics using bioconjugation has been mainly limited to drugs containing amine, alcohol, or thiol functional groups. Here, we report a general procedure for the preparation of benzylic N-acyl carbamates suitable for masking the amide group in important drugs such as Linezo...

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Detalles Bibliográficos
Autores principales:	Petrini, Agnese, Ievoli, Giovanni, Migliorini, Francesca, Taddei, Maurizio, Siciliano, Sofia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060004/ https://www.ncbi.nlm.nih.gov/pubmed/36985417 http://dx.doi.org/10.3390/molecules28062445

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