Whole-genome doubling drives oncogenic loss of chromatin segregation

Whole-genome doubling (WGD) is a recurrent event in human cancers and it promotes chromosomal instability and acquisition of aneuploidies(1–8). However, the three-dimensional organization of chromatin in WGD cells and its contribution to oncogenic phenotypes are currently unknown. Here we show that...

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Detalles Bibliográficos
Autores principales: Lambuta, Ruxandra A., Nanni, Luca, Liu, Yuanlong, Diaz-Miyar, Juan, Iyer, Arvind, Tavernari, Daniele, Katanayeva, Natalya, Ciriello, Giovanni, Oricchio, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060163/
https://www.ncbi.nlm.nih.gov/pubmed/36922594
http://dx.doi.org/10.1038/s41586-023-05794-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060163/
https://www.ncbi.nlm.nih.gov/pubmed/36922594
http://dx.doi.org/10.1038/s41586-023-05794-2

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