Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma

Epidermal growth factor receptor (EGFR)-mutated (mt) lung adenocarcinoma (LA) is refractory to immune checkpoint inhibitors (ICIs). However, the mechanisms have not been fully elucidated. CD8(+) T cell infiltration was significantly lower in EGFR-mt than in EGFR-wild-type LA, which was associated wi...

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Detalles Bibliográficos
Autores principales: Sumimoto, Hidetoshi, Takano, Atsushi, Igarashi, Tomoyuki, Hanaoka, Jun, Teramoto, Koji, Daigo, Yataro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060241/
https://www.ncbi.nlm.nih.gov/pubmed/36991099
http://dx.doi.org/10.1038/s41598-023-32177-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060241/
https://www.ncbi.nlm.nih.gov/pubmed/36991099
http://dx.doi.org/10.1038/s41598-023-32177-4

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