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Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades
Access to efficient enzymatic channeling is desired for improving all manner of designer biocatalysis. We demonstrate that enzymes constituting a multistep cascade can self-assemble with nanoparticle scaffolds into nanoclusters that access substrate channeling and improve catalytic flux by orders of...
Autores principales: | Breger, Joyce C., Vranish, James N., Oh, Eunkeu, Stewart, Michael H., Susumu, Kimihiro, Lasarte-Aragonés, Guillermo, Ellis, Gregory A., Walper, Scott A., Díaz, Sebastián A., Hooe, Shelby L., Klein, William P., Thakur, Meghna, Ancona, Mario G., Medintz, Igor L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060375/ https://www.ncbi.nlm.nih.gov/pubmed/36990995 http://dx.doi.org/10.1038/s41467-023-37255-9 |
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