Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice

Mutation or deletion of the SHANK3 gene, which encodes a synaptic scaffolding protein, is linked to autism spectrum disorder and Phelan-McDermid syndrome, conditions associated with social memory impairments. Shank3B knockout mice also exhibit social memory deficits. The CA2 region of the hippocampu...

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Detalles Bibliográficos
Autores principales: Cope, Elise C., Wang, Samantha H., Waters, Renée C., Gore, Isha R., Vasquez, Betsy, Laham, Blake J., Gould, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060401/
https://www.ncbi.nlm.nih.gov/pubmed/36991001
http://dx.doi.org/10.1038/s41467-023-37248-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060401/
https://www.ncbi.nlm.nih.gov/pubmed/36991001
http://dx.doi.org/10.1038/s41467-023-37248-8

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