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Locus coeruleus catecholamines link neuroticism and vulnerability to tau pathology in aging
Higher neuroticism is a risk factor for Alzheimer’s disease (AD), and is implicated in disordered stress responses. The locus coeruleus (LC)-catecholamine system is activated during perceived threat and is a centerpiece of developing models of the pathophysiology of AD, as it is the first brain regi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060440/ https://www.ncbi.nlm.nih.gov/pubmed/36191755 http://dx.doi.org/10.1016/j.neuroimage.2022.119658 |