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Locus coeruleus catecholamines link neuroticism and vulnerability to tau pathology in aging

Higher neuroticism is a risk factor for Alzheimer’s disease (AD), and is implicated in disordered stress responses. The locus coeruleus (LC)-catecholamine system is activated during perceived threat and is a centerpiece of developing models of the pathophysiology of AD, as it is the first brain regi...

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Detalles Bibliográficos
Autores principales: Parent, Jourdan H., Ciampa, Claire J., Harrison, Theresa M., Adams, Jenna N., Zhuang, Kailin, Betts, Matthew J., Maass, Anne, Winer, Joseph R., Jagust, William J., Berry, Anne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060440/
https://www.ncbi.nlm.nih.gov/pubmed/36191755
http://dx.doi.org/10.1016/j.neuroimage.2022.119658