Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are competitive antagonists of the human P2X3 receptor

Introduction: The P2X3 receptor (P2X3R), an ATP-gated non-selective cation channel of the P2X receptor family, is expressed in sensory neurons and involved in nociception. P2X3R inhibition was shown to reduce chronic and neuropathic pain. In a previous screening of 2000 approved drugs, natural produ...

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Detalles Bibliográficos
Autores principales: Grohs, Laura, Cheng, Linhan, Cönen, Saskia, Haddad, Bassam G., Bülow, Astrid, Toklucu, Idil, Ernst, Lisa, Körner, Jannis, Schmalzing, Günther, Lampert, Angelika, Machtens, Jan-Philipp, Hausmann, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060569/
https://www.ncbi.nlm.nih.gov/pubmed/37007008
http://dx.doi.org/10.3389/fphar.2023.1120360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060569/
https://www.ncbi.nlm.nih.gov/pubmed/37007008
http://dx.doi.org/10.3389/fphar.2023.1120360

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