DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice

INTRODUCTION: The incidence of Lyme disease (LD) in Canada and the United States has risen over the last decade, nearing 480,000 cases each year. Borrelia burgdorferi sensu lato, the causative agent of LD, is transmitted to humans through the bite of an infected tick, resulting in flu-like symptoms...

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Detalles Bibliográficos
Autores principales: Pfeifle, Annabelle, Thulasi Raman, Sathya N., Lansdell, Casey, Zhang, Wanyue, Tamming, Levi, Cecillon, Jonathon, Laryea, Emmanuel, Patel, Devina, Wu, Jianguo, Gravel, Caroline, Frahm, Grant, Gao, Jun, Chen, Wangxue, Chaconas, George, Sauve, Simon, Rosu-Myles, Michael, Wang, Lisheng, Johnston, Michael J. W., Li, Xuguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060826/
https://www.ncbi.nlm.nih.gov/pubmed/37006299
http://dx.doi.org/10.3389/fimmu.2023.1020134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060826/
https://www.ncbi.nlm.nih.gov/pubmed/37006299
http://dx.doi.org/10.3389/fimmu.2023.1020134

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