Conserved but not critical: Trafficking and function of Na(V)1.7 are independent of highly conserved polybasic motifs

Non-addictive treatment of chronic pain represents a major unmet clinical need. Peripheral voltage-gated sodium (Na(V)) channels are an attractive target for pain therapy because they initiate and propagate action potentials in primary afferents that detect and transduce noxious stimuli. Na(V)1.7 se...

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Detalles Bibliográficos
Autores principales: Tyagi, Sidharth, Sarveswaran, Nivedita, Higerd-Rusli, Grant P., Liu, Shujun, Dib-Hajj, Fadia B., Waxman, Stephen G., Dib-Hajj, Sulayman D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060856/
https://www.ncbi.nlm.nih.gov/pubmed/37008789
http://dx.doi.org/10.3389/fnmol.2023.1161028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060856/
https://www.ncbi.nlm.nih.gov/pubmed/37008789
http://dx.doi.org/10.3389/fnmol.2023.1161028

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