Effect of sirolimus on insulin dynamics in horses

BACKGROUND: Sirolimus, a mechanistic target of rapamycin inhibitor, suppresses insulin production in other species and has therapeutic potential for hyperinsulinemia in horses. HYPOTHESIS/OBJECTIVE: Determine the pharmacokinetics (PKs) of sirolimus and evaluate its effect on insulin dynamics in heal...

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Detalles Bibliográficos
Autores principales: de Tonnerre, Demia J., Medina Torres, Carlos E., Stefanovski, Darko, Robinson, Mary A., Kemp, Kate L., Bertin, François‐René, van Eps, Andrew W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
EQUINE
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061188/
https://www.ncbi.nlm.nih.gov/pubmed/36840433
http://dx.doi.org/10.1111/jvim.16650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061188/
https://www.ncbi.nlm.nih.gov/pubmed/36840433
http://dx.doi.org/10.1111/jvim.16650

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