Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform

[Image: see text] Protein-based biologics are highly suitable for drug development as they exhibit low toxicity and high specificity for their targets. However, for therapeutic applications, biologics must often be formulated to elevated concentrations, making insufficient solubility a critical bott...

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Detalles Bibliográficos
Autores principales: Erkamp, Nadia A., Oeller, Marc, Sneideris, Tomas, Ausserwoger, Hannes, Levin, Aviad, Welsh, Timothy J., Qi, Runzhang, Qian, Daoyuan, Lorenzen, Nikolai, Zhu, Hongjia, Sormanni, Pietro, Vendruscolo, Michele, Knowles, Tuomas P.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061369/
https://www.ncbi.nlm.nih.gov/pubmed/36930285
http://dx.doi.org/10.1021/acs.analchem.2c05495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061369/
https://www.ncbi.nlm.nih.gov/pubmed/36930285
http://dx.doi.org/10.1021/acs.analchem.2c05495

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