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Biocompatible Nanodiamonds Derived from Coal Washery Rejects: Antioxidant, Antiviral, and Phytotoxic Applications
[Image: see text] Coal washery rejects (CWRs) are a major byproduct produced in coal washery industries. We have chemically derived biocompatible nanodiamonds (NDs) from CWRs toward a wide range of biological applications. The average particle sizes of the derived blue-emitting NDs are found to be i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061642/ https://www.ncbi.nlm.nih.gov/pubmed/37008143 http://dx.doi.org/10.1021/acsomega.2c07981 |
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author | Boruah, Anusuya Roy, Kallol Thakur, Ashutosh Haldar, Saikat Konwar, Rituraj Saikia, Prasenjit Saikia, Binoy K. |
author_facet | Boruah, Anusuya Roy, Kallol Thakur, Ashutosh Haldar, Saikat Konwar, Rituraj Saikia, Prasenjit Saikia, Binoy K. |
author_sort | Boruah, Anusuya |
collection | PubMed |
description | [Image: see text] Coal washery rejects (CWRs) are a major byproduct produced in coal washery industries. We have chemically derived biocompatible nanodiamonds (NDs) from CWRs toward a wide range of biological applications. The average particle sizes of the derived blue-emitting NDs are found to be in the range of 2–3.5 nm. High-resolution transmission electron microscopy of the derived NDs depicts the crystalline structure with a d-spacing of 0.218 nm, which is attributed to the 100 lattice plane of a cubic diamond. The Fourier infrared spectroscopy, zeta potential, and X-ray photoelectron spectroscopy (XPS) data revealed that the NDs are substantially functionalized with oxygen-containing functional groups. Interestingly, the CWR-derived NDs exhibit strong antiviral properties (high inhibition of 99.3% with an IC(50) value of 7.664 μg/mL) and moderate antioxidant activity that widen the possibility of biomedical applications. In addition, toxicological effects of NDs on the wheatgrass seed germination and seedling growth showed minimal inhibition (<9%) at the highest tested concentration of 300.0 μg/mL. The study also provides intriguing prospects of CWRs for the creation of novel antiviral therapies. |
format | Online Article Text |
id | pubmed-10061642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-100616422023-03-31 Biocompatible Nanodiamonds Derived from Coal Washery Rejects: Antioxidant, Antiviral, and Phytotoxic Applications Boruah, Anusuya Roy, Kallol Thakur, Ashutosh Haldar, Saikat Konwar, Rituraj Saikia, Prasenjit Saikia, Binoy K. ACS Omega [Image: see text] Coal washery rejects (CWRs) are a major byproduct produced in coal washery industries. We have chemically derived biocompatible nanodiamonds (NDs) from CWRs toward a wide range of biological applications. The average particle sizes of the derived blue-emitting NDs are found to be in the range of 2–3.5 nm. High-resolution transmission electron microscopy of the derived NDs depicts the crystalline structure with a d-spacing of 0.218 nm, which is attributed to the 100 lattice plane of a cubic diamond. The Fourier infrared spectroscopy, zeta potential, and X-ray photoelectron spectroscopy (XPS) data revealed that the NDs are substantially functionalized with oxygen-containing functional groups. Interestingly, the CWR-derived NDs exhibit strong antiviral properties (high inhibition of 99.3% with an IC(50) value of 7.664 μg/mL) and moderate antioxidant activity that widen the possibility of biomedical applications. In addition, toxicological effects of NDs on the wheatgrass seed germination and seedling growth showed minimal inhibition (<9%) at the highest tested concentration of 300.0 μg/mL. The study also provides intriguing prospects of CWRs for the creation of novel antiviral therapies. American Chemical Society 2023-03-14 /pmc/articles/PMC10061642/ /pubmed/37008143 http://dx.doi.org/10.1021/acsomega.2c07981 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Boruah, Anusuya Roy, Kallol Thakur, Ashutosh Haldar, Saikat Konwar, Rituraj Saikia, Prasenjit Saikia, Binoy K. Biocompatible Nanodiamonds Derived from Coal Washery Rejects: Antioxidant, Antiviral, and Phytotoxic Applications |
title | Biocompatible Nanodiamonds
Derived from Coal Washery
Rejects: Antioxidant, Antiviral, and Phytotoxic Applications |
title_full | Biocompatible Nanodiamonds
Derived from Coal Washery
Rejects: Antioxidant, Antiviral, and Phytotoxic Applications |
title_fullStr | Biocompatible Nanodiamonds
Derived from Coal Washery
Rejects: Antioxidant, Antiviral, and Phytotoxic Applications |
title_full_unstemmed | Biocompatible Nanodiamonds
Derived from Coal Washery
Rejects: Antioxidant, Antiviral, and Phytotoxic Applications |
title_short | Biocompatible Nanodiamonds
Derived from Coal Washery
Rejects: Antioxidant, Antiviral, and Phytotoxic Applications |
title_sort | biocompatible nanodiamonds
derived from coal washery
rejects: antioxidant, antiviral, and phytotoxic applications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061642/ https://www.ncbi.nlm.nih.gov/pubmed/37008143 http://dx.doi.org/10.1021/acsomega.2c07981 |
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