Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines

[Image: see text] Nanomedicines and macromolecular drugs can induce hypersensitivity reactions (HSRs) with symptoms ranging from flushing and breathing difficulties to hypothermia, hypotension, and death in the most severe cases. Because many normal individuals have pre-existing antibodies that bind...

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Detalles Bibliográficos
Autores principales: Chen, Wei-An, Chang, Deng-Yuan, Chen, Bing-Mae, Lin, Yi-Chen, Barenholz, Yechezekel, Roffler, Steve R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062034/
https://www.ncbi.nlm.nih.gov/pubmed/36926834
http://dx.doi.org/10.1021/acsnano.2c12193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062034/
https://www.ncbi.nlm.nih.gov/pubmed/36926834
http://dx.doi.org/10.1021/acsnano.2c12193

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