Human Papillomavirus 16 E2 Interaction with TopBP1 Is Required for E2 and Viral Genome Stability during the Viral Life Cycle

CK2 phosphorylation of HPV16 E2 at serine 23 promotes interaction with TopBP1, and this interaction is important for E2 plasmid segregation function. Here, we demonstrate that the E2-TopBP1 interaction is critical for E2 and viral genome stability during the viral life cycle. Introduction of the S23...

Descripción completa

Detalles Bibliográficos
Autores principales: Prabhakar, Apurva T., James, Claire D., Fontan, Christian T., Otoa, Raymonde, Wang, Xu, Bristol, Molly L., Hill, Ronald D., Dubey, Aanchal, Morgan, Iain M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062148/
https://www.ncbi.nlm.nih.gov/pubmed/36840558
http://dx.doi.org/10.1128/jvi.00063-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062148/
https://www.ncbi.nlm.nih.gov/pubmed/36840558
http://dx.doi.org/10.1128/jvi.00063-23

Ejemplares similares