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Mutagenic analysis of actin reveals the mechanism of His161 flipping that triggers ATP hydrolysis
The dynamic assembly of actin is controlled by the hydrolysis of ATP, bound to the center of the molecule. Upon polymerization, actin undergoes a conformational change from the monomeric G-form to the fibrous F-form, which is associated with the flipping of the side chain of His161 toward ATP. His16...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062479/ https://www.ncbi.nlm.nih.gov/pubmed/37009486 http://dx.doi.org/10.3389/fcell.2023.1105460 |