Evaluation of 6-OxP-CD, an Oxime-based cyclodextrin as a viable medical countermeasure against nerve agent poisoning: Experimental and molecular dynamic simulation studies on its inclusion complexes with cyclosarin, soman and VX

The ability of the cyclodextrin-oxime construct 6-OxP-CD to bind and degrade the nerve agents Cyclosarin (GF), Soman (GD) and S-[2-[Di(propan-2-yl)amino]ethyl] O-ethyl methylphosphonothioate (VX) has been studied using (31)P-nuclear magnetic resonance (NMR) under physiological conditions. While 6-Ox...

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Detalles Bibliográficos
Autores principales: Lau, Edmond Y., Enright, Heather A., Lao, Victoria, Malfatti, Michael A., Mayer, Brian P., Williams, Audrey M., Valdez, Carlos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062596/
https://www.ncbi.nlm.nih.gov/pubmed/36996021
http://dx.doi.org/10.1371/journal.pone.0283181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062596/
https://www.ncbi.nlm.nih.gov/pubmed/36996021
http://dx.doi.org/10.1371/journal.pone.0283181

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