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Evaluation of 6-OxP-CD, an Oxime-based cyclodextrin as a viable medical countermeasure against nerve agent poisoning: Experimental and molecular dynamic simulation studies on its inclusion complexes with cyclosarin, soman and VX

The ability of the cyclodextrin-oxime construct 6-OxP-CD to bind and degrade the nerve agents Cyclosarin (GF), Soman (GD) and S-[2-[Di(propan-2-yl)amino]ethyl] O-ethyl methylphosphonothioate (VX) has been studied using (31)P-nuclear magnetic resonance (NMR) under physiological conditions. While 6-Ox...

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Detalles Bibliográficos
Autores principales:	Lau, Edmond Y., Enright, Heather A., Lao, Victoria, Malfatti, Michael A., Mayer, Brian P., Williams, Audrey M., Valdez, Carlos A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062596/ https://www.ncbi.nlm.nih.gov/pubmed/36996021 http://dx.doi.org/10.1371/journal.pone.0283181

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