Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC–MS/MS

AIMS: Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) methods to quantify total lurbinectedin, its plasma protein binding to derive the unbound fraction and its main metabolites 1′,3′-dihydroxy-lurbinectedin (M4) and N-desmethyl-lurbinectedin (M6) in human plasma, were...

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Detalles Bibliográficos
Autores principales: King, Nicholas, Garcia-Martinez, Soledad, Alcaraz, Eider, Grisalena, Alba, Lubomirov, Rubin, Altares, Raquel, Fernandez-Teruel, Carlos, Francesch, Andrés M., Avilés, Pablo M., Fudio, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062662/
https://www.ncbi.nlm.nih.gov/pubmed/36996147
http://dx.doi.org/10.1371/journal.pone.0283783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062662/
https://www.ncbi.nlm.nih.gov/pubmed/36996147
http://dx.doi.org/10.1371/journal.pone.0283783

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