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Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC–MS/MS
AIMS: Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) methods to quantify total lurbinectedin, its plasma protein binding to derive the unbound fraction and its main metabolites 1′,3′-dihydroxy-lurbinectedin (M4) and N-desmethyl-lurbinectedin (M6) in human plasma, were...
Autores principales: | King, Nicholas, Garcia-Martinez, Soledad, Alcaraz, Eider, Grisalena, Alba, Lubomirov, Rubin, Altares, Raquel, Fernandez-Teruel, Carlos, Francesch, Andrés M., Avilés, Pablo M., Fudio, Salvador |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062662/ https://www.ncbi.nlm.nih.gov/pubmed/36996147 http://dx.doi.org/10.1371/journal.pone.0283783 |
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