Human thymopoiesis produces polyspecific CD8(+) α/β T cells responding to multiple viral antigens

T-cell receptors (TCRs) are formed by stochastic gene rearrangements, theoretically generating >10(19) sequences. They are selected during thymopoiesis, which releases a repertoire of about 10(8) unique TCRs per individual. How evolution shaped a process that produces TCRs that can effectively ha...

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Detalles Bibliográficos
Autores principales: Quiniou, Valentin, Barennes, Pierre, Mhanna, Vanessa, Stys, Paul, Vantomme, Helene, Zhou, Zhicheng, Martina, Federica, Coatnoan, Nicolas, Barbie, Michele, Pham, Hang-Phuong, Clémenceau, Béatrice, Vie, Henri, Shugay, Mikhail, Six, Adrien, Brandao, Barbara, Mallone, Roberto, Mariotti-Ferrandiz, Encarnita, Klatzmann, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063231/
https://www.ncbi.nlm.nih.gov/pubmed/36995951
http://dx.doi.org/10.7554/eLife.81274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063231/
https://www.ncbi.nlm.nih.gov/pubmed/36995951
http://dx.doi.org/10.7554/eLife.81274

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