How autoreactive thymocytes differentiate into regulatory versus effector CD4(+) T cells after avoiding clonal deletion

Thymocytes bearing autoreactive T cell receptors (TCRs) are agonist-signaled by TCR/co-stimulatory molecules to either undergo clonal deletion or to differentiate into specialized regulatory T (T(reg)) or effector T (T(eff)) CD4(+) cells. How these different fates are achieved during development rem...

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Detalles Bibliográficos
Autores principales: Tai, Xuguang, Indart, Alyssa, Rojano, Mirelle, Guo, Jie, Apenes, Nicolai, Kadakia, Tejas, Craveiro, Marco, Alag, Amala, Etzensperger, Ruth, Badr, Mohamed Elsherif, Zhang, Flora, Zhang, Zhongmei, Mu, Jie, Guinter, Terry, Crossman, Assiatu, Granger, Larry, Sharrow, Susan, Zhou, Xuyu, Singer, Alfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063450/
https://www.ncbi.nlm.nih.gov/pubmed/36959291
http://dx.doi.org/10.1038/s41590-023-01469-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063450/
https://www.ncbi.nlm.nih.gov/pubmed/36959291
http://dx.doi.org/10.1038/s41590-023-01469-2

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