Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

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Matrix metalloproteinases (MMPs) regulate the degradation of extracellular matrix (ECM) components in biological processes. MMP activity is controlled by natural tissue inhibitors of metalloproteinases (TIMPs) that non-selectively inhibit the function of multiple MMPs via interaction with the MMPs&#...

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Detalles Bibliográficos
Autores principales: Hayun, Hezi, Coban, Matt, Bhagat, Ashok Kumar, Ozer, Eden, Alfonta, Lital, Caulfield, Thomas R., Radisky, Evette S., Papo, Niv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063552/
https://www.ncbi.nlm.nih.gov/pubmed/36997589
http://dx.doi.org/10.1038/s41598-023-32019-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063552/
https://www.ncbi.nlm.nih.gov/pubmed/36997589
http://dx.doi.org/10.1038/s41598-023-32019-3

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