A Vaccinia-based system for directed evolution of GPCRs in mammalian cells

Directed evolution in bacterial or yeast display systems has been successfully used to improve stability and expression of G protein-coupled receptors for structural and biophysical studies. Yet, several receptors cannot be tackled in microbial systems due to their complex molecular composition or u...

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Detalles Bibliográficos
Autores principales: Klenk, Christoph, Scrivens, Maria, Niederer, Anina, Shi, Shuying, Mueller, Loretta, Gersz, Elaine, Zauderer, Maurice, Smith, Ernest S., Strohner, Ralf, Plückthun, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063554/
https://www.ncbi.nlm.nih.gov/pubmed/36997531
http://dx.doi.org/10.1038/s41467-023-37191-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063554/
https://www.ncbi.nlm.nih.gov/pubmed/36997531
http://dx.doi.org/10.1038/s41467-023-37191-8

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