Excessive reactive oxygen species induce transcription-dependent replication stress

Elevated levels of reactive oxygen species (ROS) reduce replication fork velocity by causing dissociation of the TIMELESS-TIPIN complex from the replisome. Here, we show that ROS generated by exposure of human cells to the ribonucleotide reductase inhibitor hydroxyurea (HU) promote replication fork...

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Detalles Bibliográficos
Autores principales: Andrs, Martin, Stoy, Henriette, Boleslavska, Barbora, Chappidi, Nagaraja, Kanagaraj, Radhakrishnan, Nascakova, Zuzana, Menon, Shruti, Rao, Satyajeet, Oravetzova, Anna, Dobrovolna, Jana, Surendranath, Kalpana, Lopes, Massimo, Janscak, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063555/
https://www.ncbi.nlm.nih.gov/pubmed/36997515
http://dx.doi.org/10.1038/s41467-023-37341-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063555/
https://www.ncbi.nlm.nih.gov/pubmed/36997515
http://dx.doi.org/10.1038/s41467-023-37341-y

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