Mutual induced-fit mechanism drives binding between intrinsically disordered Bim and cryptic binding site of Bcl-xL

The intrinsically disordered region (IDR) of Bim binds to the flexible cryptic site of Bcl-xL, a pro-survival protein involved in cancer progression that plays an important role in initiating apoptosis. However, their binding mechanism has not yet been elucidated. We have applied our dynamic docking...

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Detalles Bibliográficos
Autores principales: Bekker, Gert-Jan, Araki, Mitsugu, Oshima, Kanji, Okuno, Yasushi, Kamiya, Narutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063584/
https://www.ncbi.nlm.nih.gov/pubmed/36997643
http://dx.doi.org/10.1038/s42003-023-04720-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063584/
https://www.ncbi.nlm.nih.gov/pubmed/36997643
http://dx.doi.org/10.1038/s42003-023-04720-6

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