A combinatorial code of neurexin-3 alternative splicing controls inhibitory synapses via a trans-synaptic dystroglycan signaling loop

Disrupted synaptic inhibition is implicated in neuropsychiatric disorders, yet the molecular mechanisms that shape and sustain inhibitory synapses are poorly understood. Here, we show through rescue experiments performed using Neurexin-3 conditional knockout mice that alternative splicing at SS2 and...

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Detalles Bibliográficos
Autores principales: Trotter, Justin H., Wang, Cosmos Yuqi, Zhou, Peng, Nakahara, George, Südhof, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063607/
https://www.ncbi.nlm.nih.gov/pubmed/36997523
http://dx.doi.org/10.1038/s41467-023-36872-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063607/
https://www.ncbi.nlm.nih.gov/pubmed/36997523
http://dx.doi.org/10.1038/s41467-023-36872-8

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