Cargando…

Hyperpolarized δ-[1- (13)C]gluconolactone imaging visualizes response to TERT or GABPB1 targeting therapy for glioblastoma

TERT promoter mutations are a hallmark of glioblastoma (GBM). Accordingly, TERT and GABPB1, a subunit of the upstream mutant TERT promoter transcription factor GABP, are being considered as promising therapeutic targets in GBM. We recently reported that the expression of TERT or GABP1 modulates flux...

Descripción completa

Detalles Bibliográficos
Autores principales:	Minami, Noriaki, Hong, Donghyun, Taglang, Celine, Batsios, Georgios, Gillespie, Anne Marie, Viswanath, Pavithra, Stevers, Nicholas, Barger, Carter J., Costello, Joseph F., Ronen, Sabrina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063634/ https://www.ncbi.nlm.nih.gov/pubmed/36997627 http://dx.doi.org/10.1038/s41598-023-32463-1

Ejemplares similares

Imaging telomerase reverse transcriptase expression in oligodendrogliomas using hyperpolarized δ-[1-(13)C]-gluconolactone
por: Batsios, Georgios, et al.
Publicado: (2023)

TBMT-01. HYPERPOLARIZED δ-[1-(13)C]GLUCONOLACTONE MONITORS TERT-INDUCED ELEVATION IN PENTOSE PHOSPHATE PATHWAY FLUX IN BRAIN TUMORS IN VIVO
por: Batsios, Georgios, et al.
Publicado: (2021)

Imaging 6-Phosphogluconolactonase Activity in Brain Tumors In Vivo Using Hyperpolarized δ-[1-(13)C]gluconolactone
por: Batsios, Georgios, et al.
Publicado: (2021)

BIMG-08. DEUTERIUM MAGNETIC RESONANCE SPECTROSCOPY USING (2)H-PYRUVATE ALLOWS NON-INVASIVE IN VIVO IMAGING OF TERT EXPRESSION IN BRAIN TUMORS
por: Batsios, Georgios, et al.
Publicado: (2021)

BIMG-02. IMAGING IMMORTALITY: TERT EXPRESSION ALTERS GLUCOSE METABOLISM IN LOW-GRADE GLIOMAS IN A MANNER THAT CAN BE LEVERAGED FOR NONINVASIVE METABOLIC IMAGING
por: Viswanath, Pavithra, et al.
Publicado: (2021)

In vivo investigation of hyperpolarized [1,3-(13)C(2)]acetoacetate as a metabolic probe in normal brain and in glioma
por: Najac, Chloé, et al.
Publicado: (2019)

In vivo detection of γ-glutamyl-transferase up-regulation in glioma using hyperpolarized γ-glutamyl-[1-(13)C]glycine
por: Batsios, Georgios, et al.
Publicado: (2020)

BIMG-05. TO BE OR NOT TO BE GLYCOLYTIC: DEUTERATED GLUCOSE-BASED ASSESSMENT OF THE WARBURG EFFECT ALLOWS NON-INVASIVE IMAGING OF TUMOR BURDEN AND TREATMENT RESPONSE IN MUTANT IDH GLIOMAS IN VIVO
por: Taglang, Celine, et al.
Publicado: (2021)

Split‐face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters
por: Jarząbek‐Perz, Sylwia, et al.
Publicado: (2023)

LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells
por: Qi, Wenchuan, et al.
Publicado: (2019)

The GABPB1 gene A/G polymorphism in Polish rowers
por: Maciejewska-Karłowska, A., et al.
Publicado: (2012)

Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features
por: Xing, Xiangling, et al.
Publicado: (2022)

Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos
por: Ihashi, Shunya, et al.
Publicado: (2023)

PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival
por: Batsios, Georgios, et al.
Publicado: (2019)

GABPB1-AS1 Promotes the Development of Osteosarcoma by Targeting SP1 and Activating the Wnt/β-Catenin Pathway
por: Chen, Jingyang, et al.
Publicado: (2022)

Non-invasive assessment of telomere maintenance mechanisms in brain tumors
por: Viswanath, Pavithra, et al.
Publicado: (2021)

Monitoring response to a clinically relevant IDH inhibitor in glioma—Hyperpolarized (13)C magnetic resonance spectroscopy approaches
por: Hong, Donghyun, et al.
Publicado: (2023)

Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring
por: Chaumeil, Myriam M., et al.
Publicado: (2016)

Investigation on the Biological Safety and Activity of a Gluconolactone-Based Lotion for Dermocosmetic Application
por: Zerbinati, Nicola, et al.
Publicado: (2023)

Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma
por: Radoul, Marina, et al.
Publicado: (2021)

MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma
por: Molloy, Abigail R, et al.
Publicado: (2020)

Metabolism of Epimedium-derived Flavonoid Glycosides in Intestinal Flora of Rabbits and Its Inhibition by Gluconolactone
por: YAO, Zhi-Hong, et al.
Publicado: (2011)

Influence of calcium sulfate incorporated with gluconolactone coagulant on the quality of whole soybean flour tofu
por: Lu, Wenjing, et al.
Publicado: (2022)

GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer
por: McKinney, Andrew M., et al.
Publicado: (2022)

Identification of a novel lncRNA GABPB1-IT1 that is downregulated and predicts a poor prognosis in non-small cell lung cancer
por: Xie, Jianjiang, et al.
Publicado: (2019)

lncRNA GABPB1 intronic transcript 1 upregulates pigment epithelium-derived factor via miR-93 to suppress cell proliferation in hepatocellular carcinoma
por: Li, Bin, et al.
Publicado: (2021)

Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters
por: Viswanath, Pavithra, et al.
Publicado: (2016)

Long Non-Coding RNA GABPB1-AS1 Augments Malignancy of Glioma Cells by Sequestering MicroRNA-330 and Reinforcing the ZNF367/Cell Cycle Signaling Pathway
por: Li, Xiulong, et al.
Publicado: (2021)

GABPB1-AS1 acts as a tumor suppressor and inhibits non-small cell lung cancer progression by targeting miRNA-566/F-box protein 47
por: LV, HUALIANG, et al.
Publicado: (2022)

Feasibility of Using Gluconolactone, Trehalose and Hydroxy-Propyl Gamma Cyclodextrin to Enhance Bendroflumethiazide Dissolution Using Lyophilisation and Physical Mixing Techniques
por: Saleh, Ashraf, et al.
Publicado: (2018)

Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling
por: Qin, Xinghua, et al.
Publicado: (2022)

Multi-echo single-shot EPI for hyperpolarized 13C cardiac metabolic imaging of small animals
por: Sigfridsson, Andreas, et al.
Publicado: (2013)

Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells
por: Viswanath, Pavithra, et al.
Publicado: (2016)

Metabolic Reprogramming in Mutant IDH1 Glioma Cells
por: Izquierdo-Garcia, Jose L., et al.
Publicado: (2015)

Dual regulation of TERT activity through transcription and splicing by ΔNP63α
por: Vorovich, Esther, et al.
Publicado: (2008)

The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
por: Kantikosum, Kornphaka, et al.
Publicado: (2019)

4-tert-Butylpyridinium triiodide–4-tert-butylpyridine (1/1)
por: He, Hongshan, et al.
Publicado: (2011)

Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer
por: Barger, Carter J., et al.
Publicado: (2022)

Transportable hyperpolarized metabolites
por: Ji, Xiao, et al.
Publicado: (2017)

Spin Noise Detection of Nuclear Hyperpolarization at 1.2 K
por: Pöschko, Maria Theresia, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_tq8v68u85m2s5qtmapmd7ldbuj