Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder

Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biol...

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Autores principales: Baldelli, Luca, Pirazzini, Chiara, Sambati, Luisa, Ravaioli, Francesco, Gentilini, Davide, Calandra-Buonaura, Giovanna, Guaraldi, Pietro, Franceschi, Claudio, Cortelli, Pietro, Garagnani, Paolo, Bacalini, Maria Giulia, Provini, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063653/
https://www.ncbi.nlm.nih.gov/pubmed/36997543
http://dx.doi.org/10.1038/s41531-023-00492-2
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author Baldelli, Luca
Pirazzini, Chiara
Sambati, Luisa
Ravaioli, Francesco
Gentilini, Davide
Calandra-Buonaura, Giovanna
Guaraldi, Pietro
Franceschi, Claudio
Cortelli, Pietro
Garagnani, Paolo
Bacalini, Maria Giulia
Provini, Federica
author_facet Baldelli, Luca
Pirazzini, Chiara
Sambati, Luisa
Ravaioli, Francesco
Gentilini, Davide
Calandra-Buonaura, Giovanna
Guaraldi, Pietro
Franceschi, Claudio
Cortelli, Pietro
Garagnani, Paolo
Bacalini, Maria Giulia
Provini, Federica
author_sort Baldelli, Luca
collection PubMed
description Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biological aging in videopolysomnography confirmed iRBD patients, videopolysomnography-negative and population-based controls. We found that iRBDs tended to be epigenetically older than controls, suggesting that accelerated aging characterizes prodromal neurodegeneration.
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spelling pubmed-100636532023-04-01 Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder Baldelli, Luca Pirazzini, Chiara Sambati, Luisa Ravaioli, Francesco Gentilini, Davide Calandra-Buonaura, Giovanna Guaraldi, Pietro Franceschi, Claudio Cortelli, Pietro Garagnani, Paolo Bacalini, Maria Giulia Provini, Federica NPJ Parkinsons Dis Brief Communication Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biological aging in videopolysomnography confirmed iRBD patients, videopolysomnography-negative and population-based controls. We found that iRBDs tended to be epigenetically older than controls, suggesting that accelerated aging characterizes prodromal neurodegeneration. Nature Publishing Group UK 2023-03-30 /pmc/articles/PMC10063653/ /pubmed/36997543 http://dx.doi.org/10.1038/s41531-023-00492-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Baldelli, Luca
Pirazzini, Chiara
Sambati, Luisa
Ravaioli, Francesco
Gentilini, Davide
Calandra-Buonaura, Giovanna
Guaraldi, Pietro
Franceschi, Claudio
Cortelli, Pietro
Garagnani, Paolo
Bacalini, Maria Giulia
Provini, Federica
Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder
title Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder
title_full Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder
title_fullStr Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder
title_full_unstemmed Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder
title_short Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder
title_sort epigenetic clocks suggest accelerated aging in patients with isolated rem sleep behavior disorder
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063653/
https://www.ncbi.nlm.nih.gov/pubmed/36997543
http://dx.doi.org/10.1038/s41531-023-00492-2
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