Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation

SINE-VNTR-Alu (SVA) retrotransposons arose and expanded in the genome of hominoid primates concurrent with the slowing of brain maturation. We report genes with intronic SVA transposons are enriched for neurodevelopmental disease and transcribed into long non-coding SVA-lncRNAs. Human-specific SVAs...

Descripción completa

Detalles Bibliográficos
Autores principales: Nadler, Monica J. S., Chang, Weipang, Ozkaynak, Ekim, Huo, Yuda, Nong, Yi, Boillot, Morgane, Johnson, Mark, Moreno, Antonio, Matthew P. Anderson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063665/
https://www.ncbi.nlm.nih.gov/pubmed/36997626
http://dx.doi.org/10.1038/s42003-023-04683-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063665/
https://www.ncbi.nlm.nih.gov/pubmed/36997626
http://dx.doi.org/10.1038/s42003-023-04683-8

Ejemplares similares