CLL stereotyped B-cell receptor immunoglobulin sequences are recurrent in the B-cell repertoire of healthy individuals: Apparent lack of central and early peripheral tolerance censoring

INTRODUCTION: The leukemic cells of patients with chronic lymphocytic leukemia (CLL) are often unique, expressing remarkably similar IGHV-IGHD-IGHJ gene rearrangements, “stereotyped BCRs”. The B-cell receptors (BCRs) on CLL cells are also distinctive in often deriving from autoreactive B lymphocytes...

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Detalles Bibliográficos
Autores principales: Vergani, Stefano, Bagnara, Davide, Agathangelidis, Andreas, Ng, Anita Kar Yun, Ferrer, Gerardo, Mazzarello, Andrea N., Palacios, Florencia, Yancopoulos, Sophia, Yan, Xiao-Jie, Barrientos, Jaqueline C., Rai, Kanti R., Stamatopoulos, Kostas, Chiorazzi, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063922/
https://www.ncbi.nlm.nih.gov/pubmed/37007084
http://dx.doi.org/10.3389/fonc.2023.1112879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063922/
https://www.ncbi.nlm.nih.gov/pubmed/37007084
http://dx.doi.org/10.3389/fonc.2023.1112879

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