Cargando…

4‐octyl itaconate improves the viability of D66H cells by regulating the KEAP1‐NRF2‐GCLC/HO‐1 pathway

As a novel nuclear factor E2‐related factor 2 (NRF2) activator, the itaconate has shown significant therapeutic potential for oxidative stress diseases. However, its role in Vohwinkel syndrome in relation to the gap junction protein beta 2 (GJB2) mutation is still unclear. This study aimed at invest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yanrui, Wang, Zhenying, Song, Yali, Chen, Nan, Guo, Jing, Liu, Wenmin, Guo, Keying, Ling, Xia, Zhang, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064036/ https://www.ncbi.nlm.nih.gov/pubmed/36916028 http://dx.doi.org/10.1111/jcmm.17708

Ejemplares similares

Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide
por: Liu, Hua, et al.
Publicado: (2018)

Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system
por: Xin, Liangjing, et al.
Publicado: (2022)

4‐octyl Itaconate inhibits lipopolysaccharide (LPS)‐induced osteoarthritis via activating Nrf2 signalling pathway
por: Zhang, Qingchen, et al.
Publicado: (2022)

Four-Octyl Itaconate Attenuates UVB-Induced Melanocytes and Keratinocytes Apoptosis by Nrf2 Activation-Dependent ROS Inhibition
por: Xie, Yongyi, et al.
Publicado: (2022)

4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2
por: Diskin, Ciana, et al.
Publicado: (2023)

Four-octyl itaconate activates Nrf2 cascade to protect osteoblasts from hydrogen peroxide-induced oxidative injury
por: Zheng, Yuehuan, et al.
Publicado: (2020)

The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis
por: Henderson, John, et al.
Publicado: (2021)

7-deacetylgedunin suppresses inflammatory responses through activation of Keap1/Nrf2/HO-1 signaling
por: Chen, Jian-Yu, et al.
Publicado: (2017)

4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis
por: Zhang, Peng, et al.
Publicado: (2022)

Dimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO‐1 signaling pathway
por: Gu, Lingwen, et al.
Publicado: (2020)

4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling
por: Xu, Lujun, et al.
Publicado: (2023)

Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis
por: Yang, Wenchang, et al.
Publicado: (2022)

4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1
por: Ribó-Molina, Pau, et al.
Publicado: (2023)

Downregulation of LncRNA GCLC-1 Promotes Microcystin-LR-Induced Malignant Transformation of Human Liver Cells by Regulating GCLC Expression
por: Huang, Xinglei, et al.
Publicado: (2023)

4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes
por: He, Sunyue, et al.
Publicado: (2023)

Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway
por: Nishikawa, Sakiko, et al.
Publicado: (2020)

Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ(2)-mediated cell death
por: Koyani, Chintan N., et al.
Publicado: (2016)

4-Octyl-itaconate and dimethyl fumarate inhibit COX2 expression and prostaglandin production in macrophages
por: Diskin, Ciana, et al.
Publicado: (2021)

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
por: Liao, Shan-Ting, et al.
Publicado: (2019)

4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation
por: Li, Yang, et al.
Publicado: (2020)

Mechanisms underlying the therapeutic effects of 4-octyl itaconate in treating sepsis based on network pharmacology and molecular docking
por: Chen, Maolin, et al.
Publicado: (2022)

4-Octyl Itaconate Prevents Free Fatty Acid-Induced Lipid Metabolism Disorder through Activating Nrf2-AMPK Signaling Pathway in Hepatocytes
por: Chu, Xu, et al.
Publicado: (2022)

Effects of calcium dobesilate on Nrf2, Keap1 and HO-1 in the lenses of D-galactose-induced cataracts in rats
por: Sun, Jinfeng, et al.
Publicado: (2018)

Nestin Regulates Keap1-Nrf2-HO-1-Mediated Antioxidant Responses during Stress and Malignant Hematopoiesis
por: Lu, Chunjuan, et al.
Publicado: (2022)

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
por: Olagnier, David, et al.
Publicado: (2020)

Four-Octyl Itaconate Protects Chondrocytes against H(2)O(2)-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling
por: Zhang, Peng, et al.
Publicado: (2022)

Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways
por: Seo, Hye-Young, et al.
Publicado: (2020)

Regulation of Superoxide by BAP31 through Its Effect on p22(phox) and Keap1/Nrf2/HO-1 Signaling Pathway in Microglia
por: Liu, Xia, et al.
Publicado: (2021)

Dimethyl itaconate protects against lipopolysaccharide-induced endometritis by inhibition of TLR4/NF-κB and activation of Nrf2/HO-1 signaling pathway in mice
por: Xu, Mingyue, et al.
Publicado: (2020)

Itaconic Acid Based Surfactants: I. Synthesis and Characterization of Sodium n-Octyl Sulfoitaconate Diester Anionic Surfactant
por: Xu, Jun, et al.
Publicado: (2016)

Microglia-dependent neuroprotective effects of 4-octyl itaconate against rotenone-and MPP+-induced neurotoxicity in Parkinson’s disease
por: Xia, Ning, et al.
Publicado: (2023)

The Chinese herbal formula Free and Easy Wanderer ameliorates oxidative stress through KEAP1-NRF2/HO-1 pathway
por: Hong, Chunlan, et al.
Publicado: (2017)

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway
por: Li, Jiucui, et al.
Publicado: (2021)

Mechanism of Hyperbaric Oxygen Combined with Astaxanthin Mediating Keap1/Nrf2/HO-1 Pathway to Improve Exercise Fatigue in Mice
por: Zhang, Zheng, et al.
Publicado: (2022)

The KEAP1–NRF2 System in Cancer
por: Taguchi, Keiko, et al.
Publicado: (2017)

Keap1/Nrf2 Signaling Pathway
por: Sykiotis, Gerasimos P.
Publicado: (2021)

Dimethyl itaconate inhibits LPS-induced microglia inflammation and inflammasome-mediated pyroptosis via inducing autophagy and regulating the Nrf-2/HO-1 signaling pathway
por: Yang, Su, et al.
Publicado: (2021)

Expression and correlation of NRF2, KEAP1, NQO-1 and HO-1 in advanced squamous cell carcinoma of the larynx and their association with clinicopathologic features
por: Li, Changjiang, et al.
Publicado: (2016)

Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
por: Olagnier, David, et al.
Publicado: (2020)

Upregulation of microRNA-125b-5p alleviates acute liver failure by regulating the Keap1/Nrf2/HO-1 pathway
por: Tao, Ya-Chao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qsbr3l7p2bu5hcpt05akqvm9nq