Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein–Protein Interaction as a Molecular Glue Drug Discovery Approach

[Image: see text] Molecules that stabilize protein–protein interactions (PPIs) are invaluable as tool compounds for biophysics and (structural) biology, and as starting points for molecular glue drug discovery. However, identifying initial starting points for PPI stabilizing matter is highly challen...

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Detalles Bibliográficos
Autores principales: Somsen, Bente A., Schellekens, Rick J.C., Verhoef, Carlo J.A., Arkin, Michelle R., Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064330/
https://www.ncbi.nlm.nih.gov/pubmed/36926879
http://dx.doi.org/10.1021/jacs.2c12781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064330/
https://www.ncbi.nlm.nih.gov/pubmed/36926879
http://dx.doi.org/10.1021/jacs.2c12781

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