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rt269L-Type hepatitis B virus (HBV) in genotype C infection leads to improved mitochondrial dynamics via the PERK–eIF2α–ATF4 axis in an HBx protein-dependent manner

BACKGROUND: In our previous report, the rt269I type versus the rt269L type in genotype C2 infection led to poor clinical outcomes and enhanced mitochondrial stress in infected hepatocytes. Here, we sought to investigate differences between the rt269L and rt269I types in mitochondrial functionality i...

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Detalles Bibliográficos
Autores principales: Choi, Yu-Min, Kim, Dong Hyun, Jang, Junghwa, Choe, Won Hyeok, Kim, Bum-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064691/
https://www.ncbi.nlm.nih.gov/pubmed/36997871
http://dx.doi.org/10.1186/s11658-023-00440-1