The importance of including the C-terminal domain of PTP1B(1-400) to identify potential antidiabetic inhibitors

In the present work, we studied the inhibitory and kinetic implications of classical PTP1B inhibitors (chlorogenic acid, ursolic acid, suramin) using three enzyme constructs (hPTP1B(1-285), hPTP1B(1-321), and hPTP1B(1-400)). The results indicate that the unstructured region of PTP1B (300-400 amino a...

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Detalles Bibliográficos
Autores principales: Coronell-Tovar, Andrea, Cortés-Benítez, Francisco, González-Andrade, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064822/
https://www.ncbi.nlm.nih.gov/pubmed/36997321
http://dx.doi.org/10.1080/14756366.2023.2170369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064822/
https://www.ncbi.nlm.nih.gov/pubmed/36997321
http://dx.doi.org/10.1080/14756366.2023.2170369

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