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The importance of including the C-terminal domain of PTP1B(1-400) to identify potential antidiabetic inhibitors
In the present work, we studied the inhibitory and kinetic implications of classical PTP1B inhibitors (chlorogenic acid, ursolic acid, suramin) using three enzyme constructs (hPTP1B(1-285), hPTP1B(1-321), and hPTP1B(1-400)). The results indicate that the unstructured region of PTP1B (300-400 amino a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064822/ https://www.ncbi.nlm.nih.gov/pubmed/36997321 http://dx.doi.org/10.1080/14756366.2023.2170369 |