Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization

The cryo-EM structure of a natural AlkB–AlkG fusion from Fontimonas thermophila reveals the mechanistic basis for its selectivity towards, and functionalization of, alkane terminal C–H groups. AlkB contains an alkane entry tunnel and a diiron active site, and AlkG docks through electrostatic interac...

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Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Research Briefing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064941/
https://www.ncbi.nlm.nih.gov/pubmed/37002482
http://dx.doi.org/10.1038/s41594-023-00964-2
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description The cryo-EM structure of a natural AlkB–AlkG fusion from Fontimonas thermophila reveals the mechanistic basis for its selectivity towards, and functionalization of, alkane terminal C–H groups. AlkB contains an alkane entry tunnel and a diiron active site, and AlkG docks through electrostatic interactions and transfers electrons to the diiron center for catalysis.
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spelling pubmed-100649412023-04-03 Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization Nat Struct Mol Biol Research Briefing The cryo-EM structure of a natural AlkB–AlkG fusion from Fontimonas thermophila reveals the mechanistic basis for its selectivity towards, and functionalization of, alkane terminal C–H groups. AlkB contains an alkane entry tunnel and a diiron active site, and AlkG docks through electrostatic interactions and transfers electrons to the diiron center for catalysis. Nature Publishing Group US 2023-03-31 2023 /pmc/articles/PMC10064941/ /pubmed/37002482 http://dx.doi.org/10.1038/s41594-023-00964-2 Text en © Springer Nature America, Inc. 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Briefing
Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization
title Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization
title_full Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization
title_fullStr Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization
title_full_unstemmed Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization
title_short Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization
title_sort structure of alkb–alkg shows details of alkane terminal c–h selectivity and functionalization
topic Research Briefing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064941/
https://www.ncbi.nlm.nih.gov/pubmed/37002482
http://dx.doi.org/10.1038/s41594-023-00964-2

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