BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils

Sepsis pathogenesis is complex and heterogeneous; hence, a precision-medicine strategy is needed. Acute kidney injury (AKI) following sepsis portends higher mortality. Overproduction of mitochondrial ROS (mtROS) is a potential mediator of sepsis and sepsis-induced AKI. BAM15, a chemical uncoupler, d...

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Detalles Bibliográficos
Autores principales: Tsuji, Naoko, Tsuji, Takayuki, Yamashita, Tetsushi, Hayase, Naoki, Hu, Xuzhen, Yuen, Peter S.T., Star, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065071/
https://www.ncbi.nlm.nih.gov/pubmed/36757801
http://dx.doi.org/10.1172/JCI152401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065071/
https://www.ncbi.nlm.nih.gov/pubmed/36757801
http://dx.doi.org/10.1172/JCI152401

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