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BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils

Sepsis pathogenesis is complex and heterogeneous; hence, a precision-medicine strategy is needed. Acute kidney injury (AKI) following sepsis portends higher mortality. Overproduction of mitochondrial ROS (mtROS) is a potential mediator of sepsis and sepsis-induced AKI. BAM15, a chemical uncoupler, d...

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Detalles Bibliográficos
Autores principales:	Tsuji, Naoko, Tsuji, Takayuki, Yamashita, Tetsushi, Hayase, Naoki, Hu, Xuzhen, Yuen, Peter S.T., Star, Robert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065071/ https://www.ncbi.nlm.nih.gov/pubmed/36757801 http://dx.doi.org/10.1172/JCI152401

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