Cancer-associated fibroblast-secreted glucosamine alters the androgen biosynthesis program in prostate cancer via HSD3B1 upregulation

After androgen deprivation, prostate cancer frequently becomes castration resistant (CRPC), with intratumoral androgen production from extragonadal precursors that activate the androgen receptor pathway. 3β-Hydroxysteroid dehydrogenase-1 (3βHSD1) is the rate-limiting enzyme for extragonadal androgen...

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Detalles Bibliográficos
Autores principales: Cui, Di, Li, Jianneng, Zhu, Ziqi, Berk, Michael, Hardaway, Aimalie, McManus, Jeffrey, Chung, Yoon-Mi, Alyamani, Mohammad, Valle, Shelley, Tiwari, Ritika, Han, Bangmin, Goudarzi, Maryam, Willard, Belinda, Sharifi, Nima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065083/
https://www.ncbi.nlm.nih.gov/pubmed/37009898
http://dx.doi.org/10.1172/JCI161913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065083/
https://www.ncbi.nlm.nih.gov/pubmed/37009898
http://dx.doi.org/10.1172/JCI161913

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